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目的 :探讨左氧氟沙星对于肺结核患者血清降钙素原(PCT)、超敏C反应蛋白(Hs-CRP)水平以及临床疗效的影响。方法 :选择2013年1月~2015年12月在河北省胸科医院明确诊断复治涂阳肺结核患者80例,随机分成实验组(左氧氟沙星+常规抗结核药)、对照组(常规抗结核药),比较两组患者痰涂片转阴率、X线胸片以及PCT、CRP水平。结果 :实验组痰菌阴转率显著高于对照组。实验组组总有效率为90%显著高于对照组的67.5%。治疗后两组患者PCT、CRP水平均明显降低。CRP水平较对照组患者明显降低,而PCT水平无明显差异。结论 :左氧氟沙星联合抗结核药物可以改善肺结核患者PCT、CRP水平,有一定的临床疗效。
Objective: To investigate the effect of levofloxacin on the level of serum procalcitonin (PCT), high-sensitivity C-reactive protein (Hs-CRP) and clinical efficacy in patients with pulmonary tuberculosis. Methods: From January 2013 to December 2015, 80 patients with relapsed smear positive pulmonary tuberculosis in Hebei Chest Hospital were randomly divided into experimental group (levofloxacin + conventional anti-TB drug), control group (conventional anti-TB drug) The sputum smear negative conversion rate, X-ray and PCT, CRP levels were compared between the two groups. Results: The test group sputum negative conversion rate was significantly higher than the control group. The total effective rate of the experimental group was 90% significantly higher than 67.5% of the control group. After treatment, PCT and CRP levels in both groups were significantly decreased. CRP levels were significantly lower than the control group patients, while the PCT level no significant difference. Conclusion: Levofloxacin combined with anti-TB drugs can improve the level of PCT and CRP in patients with pulmonary tuberculosis, and have certain clinical efficacy.