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目的探究热淋清颗粒联合左氧氟沙星在治疗慢性细菌性前列腺炎中的疗效价值。方法选择2015年5月—2016年5月在本院就诊治疗慢性细菌性前列腺炎的患者96例,随机分成观察组和对照组各48例,给予对照组患者口服左氧氟沙星片,0.5 g/次,1次/d;观察组患者在对照组的基础上口服热淋清颗粒,4 g/次,3次/d,待到两组患者均治疗4周后,比较两组患者的临床治疗效果,治疗前、后的临床指标以及治疗后的不良反应的发生情况。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组患者治疗有效率为97.92%,对照组患者治疗有效率为79.17%,两组对比差异有统计学意义(P<0.05)。观察组和对照组患者治疗后的前列腺液中白细胞(white blood cellexpressed prostatic secretious,EPS-WBC)和慢性前列腺症状评分(symptom index of chronic prostatitis,CPSI)指标均显著低于治疗前相应指标,治疗后,观察组患者的EPS-WBC和CPSI指标显著低于对照组相应指标[(3.16±0.78)、(17.56±0.85)、(8.51±0.82)、(17.58±1.03)个、(3.28±0.81)、(19.22±1.56)、(7.42±1.39)、(18.99±1.36)分],两组对比差异均有统计学意义(均P<0.05)。观察组患者治疗后共有3例患者出现不良反应,其不良反应发生率为6.25%,对照组患者治疗后共4例患者出现不良反应,其不良反应发生率为8.33%,两组对比差异无统计学意义(P>0.05)。结论热淋清颗粒联合左氧氟沙星在治疗慢性细菌性前列腺炎中具有很好的临床效果,能够有效地改善临床症状,安全可靠,并且治疗后的不良反应较小,在临床中可以广泛应用。
Objective To investigate the effect of heat-clearing granule combined with levofloxacin in the treatment of chronic bacterial prostatitis. Methods A total of 96 patients with chronic bacterial prostatitis who were treated in our hospital from May 2015 to May 2016 were randomly divided into observation group (48 cases) and control group (48 cases). Patients in the control group were given oral levofloxacin tablets (0.5 g / 1 times / d; observation group patients on the basis of the control group oral rerizine granules, 4 g / times, 3 times / d until both groups of patients were treated for 4 weeks, the clinical efficacy of the two groups were compared, Before and after treatment, clinical indicators and the incidence of adverse reactions after treatment. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The effective rate of treatment was 97.92% in observation group and 79.17% in control group, the difference between the two groups was statistically significant (P <0.05). The indexes of white blood cellexpressed prostatic secretious (EPS-WBC) and symptom index of chronic prostatitis (CPSI) in observation group and control group were significantly lower than those before treatment, after treatment . The indexes of EPS-WBC and CPSI in the observation group were significantly lower than those in the control group [(3.16 ± 0.78), (17.56 ± 0.85), (8.51 ± 0.82), (17.58 ± 1.03), (3.28 ± 0.81), (19.22 ± 1.56), (7.42 ± 1.39) and (18.99 ± 1.36) points respectively. There was significant difference between the two groups (all P <0.05). A total of 3 patients in the observation group showed adverse reactions after treatment, the incidence of adverse reactions was 6.25%. In the control group, 4 patients showed adverse reactions after treatment, the incidence of adverse reactions was 8.33%, there was no statistical difference between the two groups Significance (P> 0.05). Conclusion Heat clearing granule combined with levofloxacin in the treatment of chronic bacterial prostatitis has a very good clinical effect, can effectively improve the clinical symptoms, safe and reliable, and the adverse reactions after treatment is small, it can be widely used in clinical practice.