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作者采用多中心随机对照双盲方法评价了伊洛前列素(Iloprost,IT)与小剂量阿司匹林(AN)治疗血栓闭塞性脉管炎(TAO)伴严重肢体缺血的疗效。方法 152例TAO伴严重肢体缺血患者随机接受IT(每分钟0.5～2.0 ng/kg)或AN(每天100 mg)28天。152例患者中,最终19例不完全符合TAO诊断标准,故予以除外。结果 133例TAO伴严重肢体缺血患者中,68例接受IT,65例接受AN。全部患者均吸烟达11～20年,每天吸烟21～40支。
The authors evaluated the efficacy of Iloprost (IT) and low-dose aspirin (AN) in the treatment of thromboangiitis obliterans (TAO) with severe limb ischemia using a multicenter, randomized, double-blind approach. Methods A total of 152 TAO patients with severe limb ischemia were randomly assigned to IT (0.5-2.0 ng / kg per minute) or AN (100 mg daily) for 28 days. Among the 152 patients, the final 19 cases did not completely meet the diagnostic criteria of TAO, so it was excluded. Results Of 133 patients with TAO with severe limb ischemia, 68 received IT and 65 received AN. All patients smoked for 11 to 20 years, 21 to 40 cigarettes a day.