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炎症在冠心病的发病中扮演着重要的角色,血清TNF-α、IL-6、IL-18、CRP、高敏CRP(hsCRP)及CXCL16的水平是冠心病患者动脉粥样硬化预测因子,高迁移率组蛋白B1(HMGB1)与TNF-α、IL-6、hs-CRP等细胞因子一样,已经被确认为一种新的致炎因子,大量的活体证据显示:HMGB1是一种新的冠状动脉粥样硬化预测因子:首先,有证据显示动脉粥样硬化斑块能使血清HMGB1水平明显升高,且这种升高在冠心病患者更为显著,其次,HMGB1与炎症细胞活素类物质之间有相互作用,最后,HMGB1受体(RAGE,.TLR2 and TLR4)的表达与冠状动脉粥样硬化的程度及范围有关。因此HMGB1是冠状动脉硬化性心脏病的一个重要的炎症预测因子。
Inflammation plays an important role in the pathogenesis of coronary heart disease. The levels of serum TNF-α, IL-6, IL-18, CRP, hsCRP and CXCL16 are the predictors of atherosclerosis, Histone B1 (HMGB1), like TNF-α, IL-6, hs-CRP and other cytokines has been identified as a new proinflammatory cytokine, a large number of in vivo evidence showed that: HMGB1 is a new coronary artery Predictors of Atherosclerosis: First, there is evidence that atherosclerotic plaques make serum HMGB1 levels significantly higher, and this increase is more pronounced in patients with coronary heart disease. Second, HMGB1 is associated with inflammatory cytokines Finally, the expression of HMGB1 receptors (RAGE, TLR2 and TLR4) is related to the extent and extent of coronary atherosclerosis. HMGB1 is therefore an important inflammatory predictor of coronary heart disease.