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为研究全反式维甲酸（ＲＡ）与８－甲氧基补骨脂素（８－ＭＯＰ）联合应用对２种口腔鳞癌细胞系的抑制作用特点，应用ＭＴＴ法测试并绘制药物抑制曲线，用倒置显微镜观察细胞形态变化。结果表明：３０％细胞生长抑制时，联合用药合并指数（ＣＩ３０）不大于０．８２；５０％细胞生长抑制时，联合用药联合并指数（ＣＩ５０）在０．９到０．９５之间，表明两药联合应用对２种口腔鳞癌细胞系呈现协同效应。单独应用ＲＡ、８－ＭＯＰ或二者联合应用，有类似凋亡小体样结构出现。合适浓度的ＲＡ与８－ＭＯＰ联合应用的临床价值有待进一步研究
To investigate the inhibitory effect of combination of all-trans retinoic acid (RA) and 8-methoxy psoralen (8-MOP) on two kinds of oral squamous cell carcinoma cell lines, MTT assay was used to test and draw the drug inhibition curve. Inverted microscope was used to observe the changes of cell morphology. The results showed that when the cell growth inhibition was 30%, the combined medication index (CI30) was no more than 0.82; when the cell growth was inhibited by 50%, the combined medication combined index (CI50) was between 0.9 and 0.95 The two drugs combined application of two kinds of oral squamous cell carcinoma cell lines showed a synergistic effect. RA, 8-MOP alone, or a combination of both, appeared similar to apoptotic bodies. The clinical value of appropriate concentration of RA combined with 8-MOP remains to be further studied