目的　制备诺氟沙星控释胶囊 ,减少给药次数 ,提高疗效。方法　采用二氯甲烷 -正己烷系统制备诺氟沙星微囊 ,再加微囊重量 2 0 %的诺氟沙星原料药制成控释胶囊 ,并进行体外释放度研究。结果　诺氟沙星控释胶囊释药基本达零级过程 ,通过零级方程拟合 ,r =0 .96 75。加入诺氟沙星原料药作为速释部分可提高控释胶囊的释药速度。结论　用诺氟沙星微囊制成控释胶囊 ,方法可行 ,达到了控释目的 Objective To prepare norfloxacin controlled release capsules to reduce the frequency of administration and improve the curative effect. Methods Norfloxacin microcapsules were prepared by dichloromethane-n-hexane system and controlled release capsules were prepared from Norfloxacin raw materials with 20% by weight microcapsules. The in vitro release was studied. Results Norfloxacin controlled release capsules basically reached the zero-order process, through the zero-order equation fitting, r = 0.9675. Add Norfloxacin API as an immediate release part can increase the release rate of controlled release capsules. Conclusion Norfloxacin microcapsules made of controlled release capsules, the method is feasible, to achieve the purpose of controlled release