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长期以来,人们对甲状腺机能亢进症(简称甲亢)的发生机理进行了大量的研究,曾提出过许多不同的见解,如垂体异常学说、TSH受体异常学说等等,但是都未能很好地解释甲亢的发生机理。从六十年代初,又提出了所谓自身免疫学说。这一学说在近年来取得了较大的发展,受到许多学者的重视。本文就有关这方面的研究情况加以综述。一、甲状腺刺激抗体 1956年,Adams发现甲亢患者血清中有一种与TSH不同的甲状腺刺激物,因该物质能使实验动物释放~(131)Ⅰ达到高峰
For a long time, a great deal of research has been done on the mechanism of hyperthyroidism. Many different opinions have been put forward, such as abnormal pituitary theory, abnormal TSH receptor theory, etc., Explain the mechanism of hyperthyroidism. From the early 1960s, the so-called autoimmune theory was proposed. This theory has made great progress in recent years, which has attracted the attention of many scholars. This article reviews the research in this area. Thyroid-stimulated antibodies In 1956, Adams found that there was a thyroid stimulator different from TSH in the serum of patients with hyperthyroidism because of the release of ~ (131) I in experimental animals