用Ｃａ（ＯＨ）２ 饱和溶液在超声波作用下制备出稳定的羟基磷灰石溶胶（ ＨＡＰｓｏｌ） 。Ｘ 射线衍射， ＴＥＭ 和电子衍射测试表明溶胶中的ＨＡＰ 由针状微晶组成。体外细胞培养实验发现ＨＡＰｓｏｌ 对Ｗ２５６ 癌肉瘤细胞和艾氏腹水瘤细胞的增殖均具有较强的抑制作用， ＨＡＰｓｏｌ 与上述瘤细胞接触２４ ｈ 后其半数有效抑制浓度分别为１８９ ｍｇ／Ｌ 和２１０ ｍｇ／Ｌ。 A stable hydroxyapatite sol (HAPsol) was prepared by ultrasonication with a saturated solution of Ca(OH) 2 . X-ray diffraction, TEM and electron diffraction tests showed that the HAP in the sol consists of acicular crystallites. In vitro cell culture experiments showed that HAPsol had a strong inhibitory effect on the proliferation of W256 cancer sarcoma cells and Ehrlich ascites tumor cells. The half-effective inhibitory concentration of HAPsol in contact with the aforementioned tumor cells after 24 h exposure was 189 Mg/L and 210 mg/L.