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目的 研究转化生长因子β_2(TGFβ_2)在乳腺癌中的表达及其与乳腺癌预后的关系。方法 对86例随访5年以上乳腺癌用免疫组化法检测TGFβ_2蛋白表达。结果 TGFβ_2蛋白表达与乳腺癌肿瘤大小、组织学分级无明显相关性,而与腋淋巴结转移状况显著相关。与乳腺癌预后呈负相关,TGFβ_2阳性度越高,乳腺癌术后5年生存率越低。结论 TGFβ_2是乳腺癌预后不良因素之一,临床检测乳腺癌FGFβ_2蛋白表达可作为乳腺癌生物学行为和预后判断的指标。
Objective To study the expression of transforming growth factor β_2 (TGFβ_2) in breast cancer and its relationship with the prognosis of breast cancer. Methods Totally 86 cases of breast cancer were followed up for more than 5 years. The expression of TGFβ 2 protein was detected by immunohistochemistry. Results The expression of TGFβ 2 was not correlated with tumor size and histological grade in breast cancer, but significantly correlated with axillary lymph node metastasis. Negatively correlated with the prognosis of breast cancer. The higher the positive rate of TGFβ_2, the lower the 5-year survival rate of breast cancer after operation. Conclusion TGFβ_2 is one of the unfavorable prognostic factors in breast cancer. The detection of FGFβ_2 protein expression in breast cancer may serve as an indicator of the biological behavior and prognosis of breast cancer.