胎内接触过经已稀雌酚者约三分之一在青春期后发展成阴道腺病。以往本病较为罕见,对年龄较大妇女的病灶多用外科手术及烧灼为主要治疗方法。阴道腺病的镜下所见类似由米勒管演变来的,宫颈内膜,子宫内膜,输卵管内膜,提供了对激素的敏感性。加之本病与已稀雌酚有关,而临床上又多出现于青春期卵巢雌激素功能开始后,因之考虑用孕酮可抑制阴道腺病。作者对5例病理诊断为阴道腺病,母亲孕期均用过已稀雌酚。年龄为17—21岁,以孕酮坐药20毫克,每日二次,持续治疗12—24个月。孕酮坐药以 About one-third of the fetus exposed to already diluted estrogen develops into a vaginal adenosis after puberty. In the past the disease is relatively rare, more elderly women with surgery and burn lesions as the main treatment. Vaginal adenoscopy microscopic findings similar to the evolution of Miller tube, endocervix, endometrium, fallopian tube intima, providing hormone sensitivity. In addition, the disease has been associated with diluted estrogen, and clinically appear in adolescent ovarian estrogen function began, so consider using progesterone can inhibit vaginal adenosis. The author of 5 cases of pathological diagnosis of vaginal adenosis, mothers have used during pregnancy have diluted estrogen. Age of 17-21 years old, with progesterone sit 20 mg twice daily for 12-24 months. Progesterone sit medicine