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目的:分析深部痰液中的腺苷脱氨酶(ADA)浓度的检测在肺结核临床诊治中的应用价值;方法:将本院2015年呼吸科收治的200例肺结核患者,按照痰液涂片阴性和阳性等分为A、B两组,另选取100例健康人群作为C组,对3组患者进行深部痰液腺苷脱氨酶浓度的检测,对比3组检测结果的差异性;同时对肺结核患者进行临床治疗,对比治疗前后ADA浓度变化;结果:A、B两组的痰液中腺苷脱氨酶含量浓度均明显高于C组(P<0.05)。B组腺苷脱氨酶浓度略高于A组,但组间比较,差异无统计学意义(P>0.05)。A、B两组患者在治疗2、6个月后,其ADA水平均有所下降(P<0.05);结论:结核病患者的深部痰液腺苷脱氨酶浓度具有特异性,通过其指标可以有效完成对结核病的临床诊断工作,并且此方法安全、无痛、有效。
OBJECTIVE: To analyze the value of detecting adenosine deaminase (ADA) in deep sputum in the clinical diagnosis and treatment of pulmonary tuberculosis. Methods: 200 pulmonary tuberculosis patients admitted to our department of respiratory department in 2015 were analyzed according to sputum smear negative And positive equally divided into A, B two groups, another 100 healthy people as C group, the three groups of patients with deep sputum adenosine deaminase concentration test, comparing the difference between the three test results; the same time, tuberculosis The patients were treated with clinical treatment to compare ADA concentration before and after treatment. Results: The concentrations of adenosine deaminase in sputum of A and B groups were significantly higher than those in C group (P <0.05). The concentration of adenosine deaminase in group B was slightly higher than that in group A, but there was no significant difference between groups (P> 0.05). The levels of ADA in both A and B groups decreased after 2 and 6 months of treatment (P <0.05). CONCLUSION: The concentration of adenosine deaminase in deep sputum of patients with tuberculosis is specific, Effective completion of the clinical diagnosis of tuberculosis, and this method is safe, painless and effective.