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目的:评价抗菌药物管理策略对医院内抗菌药物使用影响。方法:2006-2008年间建立抗菌药物合理使用指导小组、推进感染控制计划、制定针对性的抗菌药物使用指南、展开教育培训、推行前瞻性抗菌药物使用监测、对临床抗菌药物使用的支持指导与反馈等。结果:咪唑类、抗真菌类、氟喹诺酮类、第三代头孢菌素和含酶抑制剂的β-内酰胺类的收治患者人均使用频度降幅排在前列。同时常用的非限制使用的一线药物使用构成比例增加,包括β-内酰胺霉敏感青霉素类、大环内酯类、第二代头孢菌素、四环素类、氨基糖苷类、磺胺类排在前列。医院抗菌药物使用量逐年递减,持续效果显著。结论:系统而有效的抗菌药物管理机制是抗菌药物合理使用的重要保障。
Objective: To evaluate the impact of antimicrobial management strategies on the use of antimicrobial agents in hospitals. Methods: From 2006 to 2008, a guiding group for the rational use of antimicrobial agents was set up to promote infection control programs, develop targeted guidelines for the use of antimicrobial agents, conduct education and training, promote the use of prospective antimicrobial agents, and provide guidance and feedback on the use of clinical antimicrobial agents Wait. Results: The frequency of decline in per capita use frequency of imidazoles, antifungals, fluoroquinolones, third generation cephalosporins and β-lactams containing enzyme inhibitor was the highest. At the same time commonly used non-restricted use of first-line drugs constitute a proportional increase, including β-lactam sensitive penicillins, macrolides, second-generation cephalosporins, tetracyclines, aminoglycosides, sulfonamides in the forefront. Hospital antimicrobial use declining year by year, sustained significant effect. Conclusion: The systematic and effective management of antimicrobial agents is an important guarantee for the rational use of antimicrobial agents.