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本文通过缩聚反应,合成了十二种新的含5-氟尿嘧啶、尿嘧啶、胸腺嘧啶和氮芥的聚磷酸酯。部分聚合物抗动物肿瘤试验结果表明,既含氮芥又含5-氟尿嘧啶的聚磷酸酯具有较好的抗癌活性,对小鼠艾氏腹水癌的抑制率可达60％。初步研究了这类聚合物组成与抗肿瘤活性的关系。
Twelve new polyphosphates containing 5-fluorouracil, uracil, thymine and nitrogen mustard were synthesized by polycondensation reaction. Part of the polymer anti-tumor animal test results show that both nitrogen mustard and 5-fluorouracil-containing polyphosphate has good anti-cancer activity, inhibition of Ehrlich ascites cancer in mice up to 60%. Preliminary study of the relationship between the composition of such polymers and anti-tumor activity.