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目的探讨川崎病(KD)患儿合并冠状动脉损伤的危险因素。方法按照KD诊断标准,对北京儿童医院2000-01-01—2004-12-31收治的644例KD患儿临床资料、治疗方法以及实验室资料进行分析。结果Pear-son卡方检验显示,患儿性别、发热持续时间、丙种球蛋白使用时间、丙种球蛋白使用剂量、血沉及C反应蛋白与KD合并冠状动脉损伤有关(P<0·05);进一步多因素Logistic回归分析显示,性别、发热持续时间、丙种球蛋白使用剂量与冠状动脉扩张显著独立相关(P<0·05)。结论对男性、发热持续时间长的KD患儿应予足够重视,早期足量使用丙种球蛋白以减少或减轻冠状动脉并发症。
Objective To investigate the risk factors of coronary artery injury in children with Kawasaki disease (KD). Methods According to KD diagnostic criteria, clinical data, treatment and laboratory data of 644 children with KD admitted to Beijing Children’s Hospital from January 2000 to January 2004 were analyzed. Results Pear-son chi-square test showed that gender, duration of fever, duration of gamma globulin use, dosages of gamma globulin, erythrocyte sedimentation rate, and C-reactive protein were associated with coronary artery injury with KD (P <0.05) Multivariate logistic regression analysis showed that gender, duration of fever, and dose of gamma globulin were significantly and independently associated with coronary artery dilation (P <0.05). Conclusion In men, KD children with long duration of fever should be given sufficient attention and sufficient use of gamma globulin early enough to reduce or reduce coronary complications.