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目的研究PVPK3 0对葛根黄豆苷元水溶解性和溶出性质的影响。方法 测量葛根黄豆苷元及其固体分散体、物理混合物的水溶解度和溶出速度 ,并用X -射线衍射、IR表征药物与PVP在固态条件下的相互作用。结果 Gibbs自由能和转移焓均小于零 ,表明葛根黄豆苷元从磷酸盐缓冲溶液中转移到PVP的磷酸盐缓冲溶液中是一自发的过程 ;X -射线衍射结果表明葛根黄豆苷元在PVP固体分散体 (药物∶PVP <1∶5)中以无定形形式存在 ;IR结果表明葛根黄豆苷元的羟基与PVP分子中的C =O之间存在相互作用。结论 葛根黄豆苷元的PVP分散体可大大提高药物溶解度和溶出速度
Objective To study the effect of PVPK30 on the solubility and dissolution properties of daidzein in water. Methods The water solubility and dissolution rate of daidzein and its solid dispersion and physical mixture were measured. X-ray diffraction and IR were used to characterize the interaction between drug and PVP in solid state. Results Gibbs free energy and transfer enthalpy were less than zero, indicating that the transfer of daidzein from phosphate buffer solution to phosphate buffer solution of PVP was a spontaneous process; X-ray diffraction results showed that Pueraria lobata glycoside was solid at PVP. The dispersion (drug: PVP <1:5) exists in an amorphous form; the IR results indicate that there is an interaction between the hydroxyl group of daidzein and the C=O in the PVP molecule. Conclusion Pueraria lobata PVP dispersion can greatly improve drug solubility and dissolution rate