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研究肺癌患者体液免疫指标血清球蛋白、IgG、IgA、IgM及补体 3(C3)、补体 4(C4)的变化及其与癌胚抗原 (CEA)的关系。方法 :用自动生化分析仪和放免法定量测定 80例肺癌患者的血清球蛋白、IgG、IgA、IgM及C3、C4及CEA的含量。肺部良性疾病肺炎和正常人为两对照组 ,运用SPSS软件进行统计。结果 :肺癌组的球蛋白、IgG、IgA比肺炎组和正常人显著升高 (P <0 0 1和P <0 0 5 ) ,C3则比正常人低 (P <0 0 5 ) ,CEA阳性和CEA阴性肺癌患者的免疫球蛋白、补体均无显著差异 (P >0 0 5 ) ,肺癌患者的CEA与IgA呈显著正相关 (P <0 0 1 )。结论 :肺癌患者的体液免疫功能增强 ,CEA与IgA呈显著正相关
To study the changes of serum globulin, IgG, IgA, IgM, complement 3 (C3) and complement 4 (C4) in patients with lung cancer and their relationship with carcinoembryonic antigen (CEA). Methods: The contents of serum globulin, IgG, IgA, IgM, C3, C4 and CEA in 80 patients with lung cancer were determined by automatic biochemical analyzer and radioimmunoassay. Lung benign disease pneumonia and normal control two groups, using SPSS software for statistics. Results: The levels of globulin, IgG and IgA in lung cancer group were significantly higher than those in pneumonia group and normal group (P <0.01 and P <0.05), C3 was lower than that in normal people (P <0 05) And CEA negative lung cancer patients with immunoglobulin, complement were no significant difference (P> 0.05), lung cancer patients with CEA and IgA was significantly correlated (P <0.01). Conclusions: The humoral immune function of patients with lung cancer is enhanced, and there is a significant positive correlation between CEA and IgA