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目的 探讨尿激酶型纤溶酶原激活物 (UPA )mRNA表达与胃癌侵袭和转移的关系。方法 采用NorthernBlot技术检测胃癌、近癌旁和远癌胃组织UPAmRNA表达。结果 胃癌、近癌旁和远癌胃组织UPAmRNA表达阳性率分别为 85 % ,31%和 10 %。早期胃癌为阴性表达 ,进展期胃癌呈显著高表达。有浆膜侵袭和淋巴结转移的胃癌呈显著高表达。结论 UPAmRNA表达可作为判断胃癌侵袭与转移的指标
Objective To investigate the relationship between the expression of urokinase-type plasminogen activator (UPA) mRNA and the invasion and metastasis of gastric cancer. Methods The Northern blot technique was used to detect the expression of UPA mRNA in gastric cancer, para-carcinoma and gastric cancer. Results The positive rates of UPA mRNA expression in gastric cancer, adjacent cancer and distant gastric cancer were 85%, 31% and 10% respectively. Early gastric cancer was negative expression, advanced gastric cancer was significantly higher expression. Gastric cancer with serosa invasion and lymph node metastasis was highly expressed. Conclusion The expression of UPA mRNA can be used as an indicator of gastric cancer invasion and metastasis