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为了探讨遗传因素在重症肌无力(MG)病因中的作用,作者对44例MG患者及其家族作了HLA抗原单倍体(haplotype)和疾病间关系的研究.病人临床分级依据Osserman和Genkins分类法.家族史由专科医生经交谈来确定.至少在一、二级亲属中证实有自身免疫情况时才认定该家族史为阳性.应用国家标准的HLA血清对44例患者及148名亲属进行了试验.并组成385人的对照组进行平行研究.临床特点;44例MG患者中,29例(66%)是女性(OR,1.9),40岁前发病者中78%是女性,40岁后发病者中性别相近.在非胸腺瘤病人中,青年发病组86%是女性.患有其它自身免疫病患者占9%,均为40岁前发病的女性,亦无胸腺瘤.家族史;13人有自身免疫病家族史,2个家族中有2名亲属受
In order to investigate the role of genetic factors in the pathogenesis of MG, 44 patients with MG and their families were studied for haplotypes and diseases.The patients’ clinical grades were classified according to Osserman and Genkins France family history by the specialist to talk to determine at least in the first and second degree relatives confirmed the case of autoimmune case was found to be positive for the family history of the application of national standards of HLA serum 44 patients and 148 relatives were (OR, 1.9) of 44 patients with MG, 78% of those with onset of disease before 40 years of age were female, and after 40 years of age Among the non-thymoma patients, 86% were young women, and 9% had other autoimmune diseases, all of whom were women with or without thymoma before age 40. Family history 13 People have a family history of autoimmune diseases and 2 relatives in 2 families