采用乙酰丙酮和三氧化二硼生成的配合物与吲哚-3-甲醛反应合成1,7-二(3-吲哚基)-1,6-庚二烯-3,5-二酮,可有效减少产生活泼亚甲基的副反应发生。经单因素实验和正交实验确定优化条件为:反应时间18 h、吲哚-3-甲醛与配合物摩尔比4∶1、正丁胺加入量0.50 mL、水浴温度75℃,此时产率可达52.4%。 Synthesis of 1,7-bis (3-indolyl) -1,6-heptadiene-3,5-dione by the reaction of indole-3-carboxaldehyde with a complex of acetylacetone and boron trioxide Effectively reduce the generation of active side effects of methylene. The optimum conditions were determined by single factor experiments and orthogonal experiments: the reaction time was 18 h, the molar ratio of indole-3-carbaldehyde to the complex was 4:1, the amount of n-butylamine was 0.50 mL, and the temperature of the water bath was 75 ℃. Up to 52.4%.