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目的:对比银翘散合煎剂、分煎剂与颗粒剂药效学作用。方法:分别用二甲苯、角叉菜胶造成小鼠和大鼠的炎证模型,用兔耳缘静脉注射伤寒Vi多糖菌苗制备家兔发热病理模型,及鸡红细胞作免疫原的血清溶血素形成。观察银翘散三种不同剂型对各种炎证反应的抑制作用,对发热家兔的解热作用,及对鸡红细胞作免疫原的血清溶血素形成的影响。结果:银翘散三种不同剂型对小鼠耳廓肿胀、大鼠足趾肿胀均有抑制作用,对致热家兔有解热作用,对小鼠鸡红细胞作免疫的血清溶血素形成有促进作用(P<0.01)。但组间无差异。结论:银翘散三种不同剂型在抗炎、解热作用和对免疫功能的影响方面无明显差异。
Objective: To compare the pharmacodynamics of Yinqiaosan decoction, decoction and granules. METHODS: The model of inflammation in mice and rats was induced with xylene and carrageenan, respectively. The pathological model of fever in rabbits was prepared by injection of Virus typhi virus bacterin vaccine into rabbit ear veins, and serum hemolysin of chicken erythrocytes was used as immunogen. form. Observe the inhibitory effect of three different dosage forms of Yinqiao San on various inflammatory responses, the antipyretic effect on fevered rabbits, and the effect on the formation of serum hemolysin as an immunogen for chicken erythrocytes. RESULTS: Three different dosage forms of Yinqiaosan could inhibit the swelling of the ear of mice and the swelling of the rat’s toes, and had antipyretic effect on rabbits with fever, and promoted the formation of serum hemolysin that was immune to mouse red blood cells. Effect (P<0.01). However, there is no difference between the groups. Conclusion: There are no significant differences in the anti-inflammatory, antipyretic effects and immune function of three different dosage forms of Yinqiaosan.