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目的:研究钙剂和异搏停联合用药对庆大霉素肾毒性防护作用的临床价值。方法:急性感染病人42例随机分组,观察组22例予葡萄糖酸钙和异搏停联用,对照组20例不用钙剂及异搏停;分别检测两组使用庆大霉素前后Scr和UNAG值,并作统计学比较。结果:观察组使用庆大霉素后Scr和UNAG均无明显升高;对照组则于庆大霉素应用7天、9天后,Scr和UNAG开始显著升高(P<0.01)且显著高于观察组(P<0.01),其异常增高例数亦显著高于观察组(P<0.05)。结论:钙剂和异搏停联用,对人类庆大霉素肾毒性损害确有防护作用。
Objective: To study the clinical value of combination of calcium and verapamil for gentamicin nephrotoxicity. Methods: Forty-two patients with acute infection were randomly divided into observation group (n = 22), calcium gluconate and verapamil (n = 20), and control group (20 patients without calcium and verapamil). Scr and UNAG Value, and for statistical comparison. Results: Scr and UNAG were not significantly increased in the observation group after gentamicin treatment. In the control group, Scr and UNAG were significantly increased (P <0.01) after gentamicin treatment for 7 days and 9 days Higher than the observation group (P <0.01), the number of abnormal increase was significantly higher than the observation group (P <0.05). Conclusion: The combination of calcium and verapamil do protective effect on human gentamicin nephrotoxicity.