论文部分内容阅读
目的探讨氨基末端脑钠肽前体(NT-pro BNP)和肌钙蛋白T(cTnT)在慢性肺源性心脏病(肺心病)患者中检测的临床意义。方法选择慢性肺心病患者的病例进行回顾性研究,入选52例在我院首诊的慢性肺心病患者。根据NT-pro BNP以及cTnT的水平,将患者分为四组,即单纯NT-pro BNP升高组(>1800pg/ml,组1)、单纯cTnT升高组(>14pg/ml,组2)、两者均升高组(组3)及对照组(NT-pro BNP≤1800pg/ml,cTnT≤14pg/ml,组4),并比较各组患者发生终点事件所需要的时间。结果各组发生终点事件所需要的时间:组1为(5.90±2.60)个月;组2为(7.00±2.30)个月;组3为(4.00±1.40)个月;组4为(11.30±3.40)个月;对各变量进行相关性分析结果,NT-pro BNP、cTnT与发生终点事件所需时间呈负相关(r=-0.515、-0.394,P<0.01或P<0.05)。结论联合检测NT-pro BNP和cTnT可评估慢性肺心病患者的再住院或死亡风险,具有重要的临床意义。
Objective To investigate the clinical significance of detection of NT-proBNP and troponin T (cTnT) in patients with chronic cor pulmonale (pulmonary heart disease). Methods The patients with chronic cor pulmonale were retrospectively studied. Fifty-two patients with chronic cor pulmonale who were diagnosed first in our hospital were enrolled. Patients were divided into four groups based on the levels of NT-pro BNP and cTnT: NT-pro BNP alone group (> 1800 pg / ml, group 1), simple cTnT group (> 14 pg / , Both of which were elevated (group 3) and control (NT-pro BNP ≤ 1800 pg / ml, cTnT ≤ 14 pg / ml, group 4), and the time required for endpoint events in each group was compared. Results The time required for endpoint events in each group was (5.90 ± 2.60) months for group 1, (7.00 ± 2.30) months for group 2, (4.00 ± 1.40) months for group 3, and 11.30 ± 3.40) months. Correlation analysis showed that NT-pro BNP and cTnT were negatively correlated with the time required for endpoint (r = -0.515, -0.394, P <0.01 or P <0.05). Conclusions The combined detection of NT-pro BNP and cTnT can assess the risk of rehospitalization or death in patients with chronic cor pulmonale and has important clinical significance.