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目的观察三桑肾气汤加减结合西医常规疗法治疗肾不纳气型稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法将144例肾不纳气型稳定期COPD患者随机分为治疗组和对照组各72例,对照组采用西医常规治疗,治疗组在常规西医治疗基础上加服三桑肾气汤。观察比较两组治疗前后中医证候积分、第1秒用力呼气肺容量占预计值百分比(FEV1%)、第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、生存质量评分的变化情况,并评价临床疗效。结果治疗组、对照组总有效率分别为85.29%、67.16%,组间疗效差异有统计学意义(P<0.05)。两组治疗后中医证候积分均较治疗前降低(P<0.05,P<0.01),且治疗组低于对照组(P<0.05)。治疗组治疗后FEV1%、FEV1/FVC高于对照组(P<0.01)。治疗组治疗后生存质量量表中日常生活能力、社会活动情况、抑郁心理症状、焦虑心理症状的评分和总积分均减少(P<0.01),且日常生活能力、抑郁心理症状、焦虑心理症状的评分及总积分改善优于对照组(P<0.05)。结论三桑肾气汤加减结合西医常规治疗对稳定期COPD肾不纳气型患者的疗效优于单纯使用西医常规疗法。
Objective To observe the clinical efficacy of “San-Sang Shen-Qi Decoction” combined with conventional western medicine in the treatment of chronic obstructive pulmonary disease (COPD) with renal non-normotensive type. Methods Seventy-four patients with stable renal failure of NAFLD were randomly divided into treatment group (72 cases) and control group (72 cases). The control group was treated routinely with western medicine. The treatment group was given conventional Western medical treatment with three-Sang Shen-Qi Decoction. The changes of TCM syndrome scores, FEV1%, FEV1 / FVC, and QOL scores before and after treatment were observed and compared between the two groups. Situation, and evaluate the clinical efficacy. Results The total effective rates in the treatment group and the control group were 85.29% and 67.16%, respectively, with significant differences between the two groups (P <0.05). The scores of TCM syndromes after treatment in both groups were lower than those before treatment (P <0.05, P <0.01), and were lower in the treatment group than those in the control group (P <0.05). After treatment, FEV1% and FEV1 / FVC in the treatment group were higher than those in the control group (P <0.01). The scores of living ability, social activities, depression, anxiety and psychological symptoms in the treatment group after treatment were decreased (P <0.01), and their daily living ability, depressive psychological symptoms, anxiety and psychological symptoms The score and total score improved better than the control group (P <0.05). Conclusion Sangshenqiqi Decoction combined with Western conventional treatment of COPD patients with non-renal gas in the treatment of patients with better than the simple use of Western conventional therapy.