据估计,约有1/3的不孕症妇女需要较长时间服用促排卵药物,如枸橼酸氯菧酚(CC)、绒毛膜促性腺激素(hCG)及绝经妇女尿促性腺激素(hMG)等。应用这些药物常会造成卵巢过度刺激综合征(Ovarian hypersti rnulation syndrome,OHSS),此外,也有报道在葡萄胎、绒毛膜上皮癌及多胎妊娠发生OHSS者。OHSS的症状轻重差异很大,轻者仅有卵巢增大及下腹不适;而重者有腹水、低血容量、血浓缩、严重的水及电解质素乱,甚至导致死亡。为此对不孕症患者进行促排卵治疗时必须注意OHSS的发生。 OHSS的发生率 OHSS的发生是与所用的药物、剂量、治疗方案、疗程长短及患者本身内分泌情况有关。在促排卵药物中最易导致OHSS的为hMG。 1.hMG:现临床上所用的hMG制剂主要是Pergonal,每安瓿Pergonal含有促卵 It is estimated that about one-third of infertile women take a longer time to take ovulation-promoting drugs such as chlorophenol citrate (CC), human chorionic gonadotropin (hCG) and menopausal women urinary gonadotropin (hMG )Wait. These drugs often cause Ovarian hyperstimulation syndrome (OHSS), in addition, there are also reports of hydatidiform mole, choriocarcinoma and multiple pregnancies occur OHSS. The symptoms of OHSS vary greatly in severity, with only ovarian enlargement and lower abdominal discomfort; those with severe ascites, hypovolemia, blood concentration, severe water and electrolyte disorders, and even death. To this end, infertility patients ovulation induction therapy must pay attention to the occurrence of OHSS. The incidence of OHSS OHSS occurs with the use of drugs, dosage, treatment options, duration of treatment and the patient’s own endocrine situation. Among ovulation drugs most likely to cause OHSS is hMG. 1.hMG: hMG preparations used clinically are mainly Pergonal, per ampule contains ampule