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用邻苯三酚自氧化法和改良硫代巴比妥酸（ＴＢＡ）荧光微量法测定了多发性骨髓瘤（ＭＭ）患者初发期、缓解期和复发期红细胞超氧化物歧化酶（ＳＯＤ）活性和血浆脂质过氧化物（ＬＰＯ）含量。结果表明：ＭＭ初发和复发病例红细胞ＳＯＤ活性明显降低，血浆中ＬＰＯ含量明显增高，较正常对照均有明显差异。缓解期患者的ＳＯＤ活性和ＬＰＯ含量大致恢复正常水平。ＭＭ红细胞ＳＯＤ活力与血浆ＬＰＯ含量呈负相关（ｒ＝－０．４２５，Ｐ＜０．０５）），与血红蛋白浓度呈正相关（ｒ＝０．７２２，Ｐ＜０．００１），与骨髓中浆细胞百分数呈负相关（ｒ＝－０．５２６，Ｐ＜０．０５）。以上结果提示自由基损伤作用参与了ＭＭ的发生、发展和转归过程，且与病情的严重程度有关。
The levels of erythrocyte superoxide dismutase (SOD) in primary, remission and relapse phases in multiple myeloma (MM) patients were determined by pyrogallol autoxidation and modified thiobarbituric acid (TBA) Activity and plasma lipid peroxidation (LPO) content. The results showed that the activity of SOD in erythrocytes of patients with initial and recurrent MM was significantly decreased, and the content of LPO in plasma was significantly higher than that of normal controls. Patients with remission SOD activity and LPO content returned to normal levels. The activity of SOD in MM erythrocytes was negatively correlated with LPO content (r = -0.425, P <0.05), and positively correlated with hemoglobin concentration (r = 0.722, P <0.001) The percentage of cells was negatively correlated (r = -0.526, P <0.05). These results suggest that the role of free radical injury involved in the occurrence, development and prognosis of MM, and the severity of the disease.