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肝细胞癌(HCC)不仅从硬化肝的特异组织中衍生,而且小肝癌也有高发性的脉管浸润(如门脉内肿瘤栓)。因此,在肝癌的发展、浸润、转移过程中,能溶解、破坏结缔组织(Ⅰ、Ⅲ骨胶原)、组织蛋白和血管壁之类肝癌障碍物的胶原分解酶类、组织蛋白酶类发挥了很大的作用。所以作者测定了肝癌边缘区蛋白酶类活性,从临床病理学角度研究了这些酶与肝癌发展和转移的关联。
Hepatocellular carcinoma (HCC) is not only derived from the specific tissues of sclerosing liver, but also small hepatocellular carcinoma has high vascular invasion (such as portal vein tumor thrombus). Therefore, during the development, invasion, and metastasis of liver cancer, collagen-degrading enzymes and cathepsins that can dissolve and destroy connective tissue (I, III collagen), tissue proteins, and blood vessel barriers, such as liver cancer, play a large role. The role. Therefore, the authors determined the activity of proteases in the marginal areas of hepatocellular carcinoma, and studied the relationship between these enzymes and the development and metastasis of hepatocellular carcinoma from the perspective of clinical pathology.