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一些高分子量药物或一些不溶于脂肪的药物,不能透过血脑屏障,因此对中枢神经系统肿瘤或中枢神经传染病不能产生治疗效果。如果一个药物能够可逆地打开血脑屏障、便于药物进入中枢神经系统,这对中枢神经系统疾病的治疗无疑是重要的。脂质体是有发展前途的药物载体,如果脂质体包埋的药物可以有效地透过血脑屏障,将会提高对中枢神经系统肿瘤或脑内其它疾病的治疗效果。本实验应用雌性 BDF_1小鼠,体重18～23g。用卵磷脂酰胆碱(PC)和胆固醇(C)制备小单层脂质体(Suv’s)。所用的二甲基亚砜(DMSO)剂量对
Some high-molecular-weight drugs or some fat-insoluble drugs can not penetrate the blood-brain barrier and thus can not have a therapeutic effect on central nervous system tumors or CNS infectious diseases. If a drug can reversibly open the blood-brain barrier and facilitate the entry of drugs into the central nervous system, it is undoubtedly important for the treatment of central nervous system diseases. Liposomes are promising drug carriers. If liposome-embedded drugs can effectively penetrate the blood-brain barrier, they will improve the therapeutic effect on tumors of the central nervous system or other diseases in the brain. Female BDF 1 mice were used in this experiment, weighing 18-23 g. Small monolayers of liposomes (Suv’s) were prepared with egg phosphatidylcholine (PC) and cholesterol (C). The dimethylsulfoxide (DMSO) dose used