论文部分内容阅读
采用小猪双侧颈动脉结扎伴失血模型检测双侧颈动脉的结扎伴失血对脑氧分压和O -酪氨酸变化的影响 ,结果发现 :小猪脑氧分压为 (5 1± 4)托 颈动脉结扎和失血后 6 0min降为 (10± 1 5 )托 (P <0 0 0 1) ,当颈动脉恢复通畅和失血再灌注后 ,脑氧分压增至 (4 0± 6 )托 ,此值与预试验时的脑氧分压无明显差异 对照组中脑纹状体中的O -酪氨酸的含量为 (0 5 7± 0 19)nmoles/ g组织 缺血试验后 1h其含量明显升为 (2 9± 0 5 )nmoles/ g组织 (P <0 0 0 5 ) ,显示缺血后再灌注导致脑纹状体O -酪氨酸显著上升 提示组织中羟基产生增加 ,可能与新生小猪脑缺血和再灌注损伤有一定作用
Bilateral carotid artery ligation with blood loss model was used to detect the effects of bilateral carotid artery ligation with blood loss on cerebral oxygenation and O-tyrosine changes. The results showed that the cerebral oxygen pressure in piglets was (5 1 ± 4) ) Was decreased to (10 ± 1 5) Torr 60 min after ligation of the carotid artery and blood loss (P 0 01). After carotid artery recovery and blood loss and reperfusion, the cerebral oxygenation pressure increased to (40 ± 6) ), No significant difference between this value and the pre-test cerebral oxygenation pressure O-tyrosine content in the striatum in the control group (0 57 ± 0 19) nmoles / g tissue ischemia test 1h significantly increased to (29 ± 0.05) nmoles / g tissue (P <0 05), indicating that the marked increase of O - tyrosine in the striatum of the striatum after ischemia and reperfusion suggested that the production of hydroxyl groups in the tissue increased , May play a role in newborn piglets with cerebral ischemia and reperfusion injury