早在1983年Feldberg等在受抗原致敏的豚鼠肺及眼镜蛇毒处理的狗肺灌注液中发现了一种能缓慢启动豚鼠十二指肠收缩的物质称为慢反应物质SRS,之后简称为SRS-A(Slow reacting substance of anaphylaxis)。哮喘病人受抗原激发后,肺中产生SRS-A,具有强烈的收缩支气管平滑肌的作用,因此推论它能导致哮喘。然而直到1979年,用半胱氨酸和离子载体A 23187激发小鼠肥大细胞产生SRS,经 As early as 1983, Feldberg et al. Found in a dog lung perfusion solution treated with antigen-primed guinea pig lung and cobra venom that a substance that can slowly start the contraction of the duodenum of guinea pigs is referred to as the slow-reacting substance SRS and is referred to as SRS -A (Slow reacting substance of anaphylaxis). After being challenged by antigen, asthmatic patients produce SRS-A in the lungs and have a strong role in contracting bronchial smooth muscle. Therefore, we conclude that it can cause asthma. However, until 1979, cysteine ​​and ionophore A 23187 stimulated mouse mast cells produce SRS