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目的：通过检测炎症牙髓、尖周组织渗出液中白细胞介素－６（ＩＬ－６）的含量，探讨ＩＬ－６与牙髓、尖周炎症的关系。方法：采用ＥＬＩＳＡ免疫夹心法进行ＩＬ－６含量检测。结果：正常牙髓组织渗出液中未检测到ＩＬ－６，炎症牙髓、尖周组织渗出液中均有不同含量ＩＬ－６检出，急性炎症组高于慢性炎症组，急性尖周炎组高于急性牙髓炎组。结论：ＩＬ－６与牙髓、尖周炎症密切相关，主要参与急性期炎症反应，在牙髓、尖周炎症病变过程中起着重要作用。
OBJECTIVE: To investigate the relationship between interleukin-6 (IL-6) and dental pulp and periapical inflammation by detecting the content of interleukin-6 (IL-6) in inflammatory pulp and periapical tissue exudate. Methods: IL-6 was detected by ELISA sandwich method. Results: IL-6 was not detected in exudate of normal pulp tissue, and IL-6 was found in exudate of inflammatory pulp and periapical tissue. The acute inflammation group was higher than that of chronic inflammation group and acute apical week Yan group was higher than acute pulpitis group. CONCLUSION: IL-6 is closely related to pulp and periapical inflammation. It is mainly involved in the acute inflammatory reaction and plays an important role in the pathogenesis of pulpitis and periapical inflammation.