固有免疫反应是由能够识别病原相关分子模式(pathogen-associated molecular patterns,PAMPs)的受体介导的,这些受体统称模式识别受体(pattern recognition receptors,PRRs),包括Toll样受体、RIG-I和MDA5等。这些模式识别受体在识别相应配体后,能通过活化下游信号,诱导炎性细胞因子和干扰素的产生,从而在抵抗和清除病原微生物的感染、维持机体免疫系统的 The innate immune response is mediated by receptors that recognize pathogen-associated molecular patterns (PAMPs), collectively known as pattern recognition receptors (PRRs), including Toll-like receptors, RIGs -I and MDA5 and so on. Recognition of the corresponding ligands by these pattern recognition receptors can activate the downstream signals and induce the production of inflammatory cytokines and interferons so as to resist and eliminate the infection of pathogenic microorganisms and maintain the immune system