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分三个剂量组给予大鼠和犬口服复方a-细辛脑两个月,于给药前、给药后一个月及给药后两个月分别检测血常规、肝和肾功能,心电图及其它指标,并在末次检查后处死动物作病理学检查。(1)大鼠:给药两个月后,90mg/kg剂量组有20%大鼠发生轻度的肝细胞点状坏死和30%大鼠轻度的SGPT升高。1只大鼠于第6周死亡,病理学检查发现肝细胞有轻度的点状坏死,认为是药物毒性所致。在给药期间有80%大鼠出现轻度厌食和腹泻反应。30mg/kg组和10mg/kg剂量组无明显不良作用。(2)犬:27mg/kg剂量组60%出现轻度厌食和20%犬有轻度腹泻反应,无肝细胞坏死及SGPT升高。18mg/kg和9mg/kg剂量组无明显不良作用。该药毒性低,安全范围大。
Rats and dogs were given oral compound a-asaron for two months in three dose groups. Blood routine, liver and kidney function, ECG and blood function were measured before administration, one month after administration, and two months after administration. Other indicators, and animals were sacrificed after the final examination for pathological examination. (1) Rats: Two months after administration, 20% of rats in the 90 mg/kg dose group had mild necrosis of hepatocytes and 30% of rats had mild SGPT elevations. One of the rats died in the 6th week. Histopathological examination revealed mild punctate necrosis of hepatocytes, thought to be due to drug toxicity. 80% of rats showed mild anorexia and diarrhea reactions during the administration period. There was no significant adverse effect in the 30 mg/kg and 10 mg/kg dose groups. (2) Canine: In the 27 mg/kg dose group, mild anorexia occurred in 60% of patients and mild diarrhea occurred in 20% of dogs. There was no hepatocyte necrosis and elevated SGPT. No significant adverse effects were observed in the 18 mg/kg and 9 mg/kg dose groups. The drug has low toxicity and large safety range.