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目的:探讨自身免疫性中枢神经系统脱髓鞘疾病慢性型的病理特点及其临床意义。方法:建立猴实验性变应性脑脊髓炎(experimentalallergicencephalomyeli-tis,EAE)模型,于首次发病后4年进行病理取材和电镜观察。结果:①活动性病灶内轴突病变十分突出。其形式包括有空泡样变性、皱缩或消失,此外也可见成片的髓鞘松解、断裂或融合,少突胶质细胞变性,以及散在的巨噬细胞。②可疑活动性病灶内轴突病变程度稍轻,以空泡变性为主,轴突完全消失及皱缩则少见,部分髓鞘与轴突的变性及散在的巨噬细胞。结论:慢性EAE的病理改变同时存在髓鞘与轴突的变性,多发性硬化(multipesclerosis,MS)后期不可逆的功能障碍可能与后者有更大的相关。
Objective: To investigate the pathological characteristics and clinical significance of chronic type of autoimmune demyelinating diseases of the central nervous system. Methods: Experimental experimental allergic encephalomyelitis (EAE) model was established in rats. Pathological examination and electron microscopy were performed 4 years after the first onset. Results: ①The lesions of axon in active lesion are very prominent. Its forms include vacuolar degeneration, shrinkage or disappearance, in addition to the patch can also be seen lysis, fracture or fusion, oligodendrocyte degeneration, and scattered macrophages. ② suspicious activity lesion lesion within the degree of lesser degree to vacuolar degeneration, axonal disappearance and shrinkage are rare, some myelin and axonal degeneration and scattered macrophages. CONCLUSION: Myelin and axon degeneration exist in the pathological changes of chronic EAE. Irreversible dysfunction in the later period of multi-sclerosis (MS) may have a greater correlation with the latter.