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五味子具有保肝利胆、抗肿瘤、抗氧化、抗过敏、抗病毒及抗溃疡等多种药理作用,而五味子制剂与他克莫司合用,可抑制细胞色素P450及P-糖蛋白(P-gp)的活性,其在维持他克莫司的血药浓度,降低移植患者他克莫司用量的实际临床治疗中的作用也引起了关注。本文综述五味子提取物及其主要成分对他克莫司代谢的影响及相关机制。
Schisandra liver and gallbladder, anti-tumor, anti-oxidation, anti-allergy, antiviral and anti-ulcer and other pharmacological effects, and Schisandra preparation combined with tacrolimus can inhibit cytochrome P450 and P-glycoprotein (P- gp), and its role in the actual clinical treatment of maintaining tacrolimus plasma concentrations and reducing the amount of tacrolimus in transplant patients has drawn attention. This article reviews the effects of the extract of Schisandra chinensis and its major components on the metabolism of tacrolimus and its related mechanisms.