着色性干皮病是一种少见的常染色体显性遗传性疾病 ,以皮肤和眼的色素改变 ,对光敏感和癌变为特征 ,笔者在 2 0 0 0年 8月 31日门诊遇到 1例 ,现报告如下。患者 :男 ,6 4岁 ,2 0年前发现双手皮肤出现黑褐色点状及米粒大小斑疹 ,多量分布 ,未引起注意 ,逐渐双手掌侧皮损有轻度角 Xeroderma pigmentosum is a rare autosomal dominant hereditary disease. It is characterized by changes in the pigments of the skin and eyes, and is sensitive to light and cancer. The author encountered one case on August 31, 2000. The report is as follows. Patient: Male, 6 4 years old, 20 years ago, his hands had dark brown spots and rice-sized macules. They were distributed in large quantities and did not attract attention. Gradually, the palmar skin lesions of both hands had slight angulations.