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促性腺激素释放激素激动剂(GnRH-a)是人工合成的GnRH衍生物,通过与垂体的GnRH受体结合可抑制垂体和卵巢功能,从而抑制垂体和卵巢性激素的分泌达降调节作用。目前,GnRH-a在临床中应用较广,对女性患者主要应用于肿瘤性疾病、子宫内膜异位症、不孕症、辅助生育技术中的促排卵、中枢性性早熟以及在化疗前或化疗同时应用以保护患者的卵巢功能。该文就GnRH-a在女性患者中的临床应用进展予以综述。
Gonadotropin-releasing hormone agonist (GnRH-a) is a synthetic GnRH derivative that inhibits pituitary and ovarian functions by binding to the pituitary GnRH receptor, thereby inhibiting the down-regulation of pituitary and ovarian hormones. At present, GnRH-a is widely used clinically, and is mainly applied to female patients for tumor-causing diseases, endometriosis, infertility, ovulation induction in assisted reproductive technology, central precocious puberty, Chemotherapy is also used to protect the patient’s ovarian function. This article reviews the clinical application of GnRH-a in female patients.