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目的 :探讨颅内血管周细胞瘤的临床特点及其治疗。方法 :回顾性分析31例颅内血管周细胞瘤患者的临床特征、影像学和病理学表现及其治疗方法,观察患者的无进展生存(progression-free survival,PFS)时间,比较不同治疗方法之间的差异。结果 :31例颅内血管周细胞瘤患者均进行了手术治疗及手术后放疗。16例患者进行了肿瘤全部切除(gross total removal,GTR)及手术后分次外放射治疗(external beam radiation therapy,EBRT)。15例患者进行了肿瘤部分切除(subtotal removal,STR),其中6例患者手术后进行了EBRT,9例患者手术后进行了伽玛刀手术(gamma knife surgery,GKS)。GTR组患者的中位PFS(89个月,64~126个月)明显长于STR组(49个月,26~81个月),差异有统计学意义(P<0.01)。而STR组中手术后接受EBRT患者的中位PFS(49个月,26~81个月)与GSK患者的中位PFS(47个月,29~78个月)之间的差异无统计学意义(P>0.05)。结论 :GTR结合手术后放疗是治疗颅内血管周细胞瘤的有效方法。
Objective: To investigate the clinical features and treatment of intracranial pericytes. Methods: The clinical features, imaging and pathology findings of 31 patients with intracranial pericytes were retrospectively analyzed. The progression-free survival (PFS) time was observed and compared with different treatment methods The difference between. Results: All 31 patients with intracranial perineural tumor were treated with surgery and postoperative radiotherapy. Sixteen patients underwent gross total removal (GTR) and postoperative external beam radiation therapy (EBRT). Fifteen patients underwent partial tumor resection (STR). Six of the patients underwent EBRT after surgery and nine patients underwent gamma knife surgery (GKS). Median PFS (89 months, 64-126 months) in the GTR group was significantly longer than in the STR group (49 months, 26-81 months) with a statistically significant difference (P <0.01). However, there was no significant difference between the median PFS (49 months, 26-81 months) and the median PFS (47 months, 29-78 months) in patients with GSK after EBRT (P> 0.05). Conclusion: GTR combined with postoperative radiotherapy is an effective method for the treatment of intracranial pericytes.