肽疫苗与普通全蛋白 (或基因免疫中的全基因 )相比有诸多优点 ,如纯度高 ,可诱生高特异性免疫应答。但是 ,合成肽诱发免疫需要毒性佐剂。脂肽作为肽疫苗的一种形式 ,早在十年前就已被发现 ,它们可以在无佐剂条件下诱生全面的免疫应答。本文介绍了脂肽疫苗的过去 ,研究进展以及与脂肽疫苗合成、配方及接种途径有关的问题。脂肽疫苗粘膜应用的进展将为抗粘膜表面感染的病原体提供理想的策略。 Peptide vaccines have many advantages over common whole proteins (or whole genes in genetic immunization), such as their high purity, which induce high specific immune responses. However, synthetic peptides induce immunity requiring toxic adjuvants. Lipopeptides, as a form of peptide vaccine, have been discovered as early as ten years ago and they can elicit an overall immune response without adjuvant. This article describes the past, the progress of lipopeptide vaccines and the problems associated with lipopeptide vaccine synthesis, formulation and route of vaccination. Advances in the use of lipopeptide vaccine mucosal membranes will provide an ideal strategy for anti-mucosal surface infection of pathogens.