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研究血管紧张素原（AGT）基因M235T多态性对NIDDM患者发生高血压的影响。方法用限制性酶谱分析法检查AGT基因M235T多态性M235和T235的频率和TT、TM和MM基因型在正常对照组（68例）、糖尿病非高血压组（104例）和糖尿病高血压组（87例）中的分布，并检查各基因型对实验对象血压水平的影响。结果糖尿病高血压组患者AGT基因M235T多态性T235的频率明显高于对照组和糖尿病非高血压组。TT基因型在糖尿病高血压组中的比例明显高于对照组和糖尿病非高血压组。TT基因型者的收困压和舒张压显著高于TM和MM基因型者。结论携带AGT多态性TT基因型者的收缩压和舒张压水平显著高于携带TM和TT基因型者；血管紧张素原基因M235T多态性的T235变异是NIDDM合并高血压的危险因素。
To investigate the effect of M235T polymorphism of angiotensinogen (AGT) gene on hypertension in patients with NIDDM. Methods The frequency of M235 and T235 of AGT gene M235T and the genotypes of TT, TM and MM were examined by restriction endonuclease analysis in the normal control group (68 cases), diabetic non-hypertensive group (104 cases) and diabetic hypertension (87 cases) in the distribution, and check the genotype on the impact of experimental subjects blood pressure levels. Results The T235 frequency of M235T polymorphism of AGT gene was significantly higher in diabetic hypertensive patients than in control subjects and diabetic non-hypertensive subjects. TT genotype in diabetic hypertensive group was significantly higher than the control group and diabetic non-hypertensive group. TT genotypes were significantly higher than the trapped pressure and diastolic blood pressure in TM and MM genotypes. Conclusions The TT and AG genotypes of TT genotypes with AGT polymorphism are significantly higher than those with TM and TT genotypes. T235 mutation of M235T polymorphism of angiotensinogen gene is a risk factor of NIDDM complicated with hypertension.