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同工酶谱是研究细胞基因表达的良好指标。近年来国外已广泛利用同工酶谱的变化来观察个体发育或组织癌变时的基因表达,其中以丙酮酸激酶(PyK)的研究较为活跃。丙酮酸激酶至少有三种同工酶;L型主要存在于哺乳动物肝脏、肾皮质等与糖异生有关的组织中;M(或 M_1)型存在于骨胳肌、心肌和脑中;而K(或M_2)型则广泛存在于除骨胳肌
Isoenzyme is a good indicator of cellular gene expression. In recent years, foreign countries have widely used changes in isoenzyme patterns to observe the individual development or tissue gene expression at the time of carcinogenesis, of which pyruvate kinase (PyK) is more active. Pyruvate kinase has at least three isozymes; L is mainly found in tissues related to gluconeogenesis, such as in mammalian liver and renal cortex; M (or M 1) is found in skeletal muscle, myocardium and brain; and K (Or M_2) type is widespread in addition to skeletal muscle