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作者分析了117例中数年龄43岁(16～84岁),平均血小板计数(PC)49×10~9/L(5～100×10~9/L)慢性原发性血小板减少性紫癜(CITP)病人出血并发症的危险因素。男30例,女87例。PC<100×10~9/L。骨髓巨核细胞数正常或增加,脾无肿大,WBC和Hb 水平正常。68/117例(58%)用强的松1～2mg/kg 治疗2～4周,若治疗>60天则每日维持剂量0.3～1mg/kg 或间歇服药,用甾类化合物治疗至少30天才评估疗效;33例切脾治疗但未达长期完全缓解(PCR)则用皮质类固醇治疗;28例对甾类化合物及切脾或不适于外科治疗的病人服炔羟雄烯异口恶唑200mg,一日三次,服2个月,并中止其他药物包括强的松治疗;6例静脉注射长春新碱1mg,每周一次,连续3次;4例服硫唑嘌呤2mg/kg,至少16周,本治疗仅用于对甾类化合物、切脾和炔羟雄烯异(口恶)唑无效病人。疗效评估:完全缓解(CR)PC>100×
The authors analyzed a total of 117 patients with chronic idiopathic thrombocytopenic purpura (median age 43 years (range, 16-84 years), mean platelet count 49 × 10-9 / L (5-100 × 10-9 / L) CITP) risk factors for bleeding complications in patients. 30 males and 87 females. PC <100 × 10 ~ 9 / L. The number of bone marrow megakaryocytes normal or increased, no enlargement of the spleen, WBC and Hb levels were normal. 68/117 (58%) treated with prednisone 1 ~ 2mg / kg for 2 ~ 4 weeks, if the treatment> 60 days, the daily maintenance dose 0.3 ~ 1mg / kg or intermittent treatment with steroids for at least 30 days 33 cases of splenectomy but not long-term complete remission (PCR) were treated with corticosteroids; 28 cases of steroid and splenectomy or unsuitable for surgical treatment of patients with alkyne androstane isooxazole 200mg, Three times a day, for 2 months, and discontinued other drugs, including prednisone treatment; 6 cases of intravenous vincristine 1mg, once a week for 3 consecutive times; 4 cases of azathioprine 2mg / kg, at least 16 weeks, This treatment is only for steroids, splenectomy and alkyne androsterone different (oxazole) invalid patients. Efficacy evaluation: Complete remission (CR) PC> 100 ×