We describe clinical and pathological features of a case of paralytic rabies w ith acute axonal neuropathy that closely resembled axonal Guillain-Barrésyndro me. This case emphasizes that there is overlap of both clinical and pathological features in paralytic rabies and axonal Guillain-Barrésyndrome. These finding s raise the possibility that infectious and autoimmune etiologies can lead to si milar morphological changes in the nerves. We describe clinical and pathological features of a case of paralytic rabies w ith acute axonal neuropathy that closely resembled axonal Guillain-Barrésyndro me. This case emphasizes that there is overlap of both clinical and pathological features in paralytic rabies and axonal Guillain-Barrésyndrome. These findings s raise the possibility that infectious and autoimmune etiologies can lead to si milar morphological changes in the nerves.