卵巢癌是女性最常见的三大恶性肿瘤之一,可发于任何年龄,多见于中老年妇女,很少发生在青春期前和婴幼儿,是女性癌症死亡的第五大原因。由于其发病隐匿,缺乏有效的筛查及早期诊断措施,致使其5年生存率仍徘徊在20%~30%,并有一个世界性的统计,每年约发生卵巢癌新病例225 500例,死亡140 200例~([1-2])。故对卵巢癌的发病机制、化疗耐药性及预后的研究至关重要。 Ovarian cancer is one of the three most common malignant tumors in women. It can occur at any age and is more common in middle-aged and elderly women, and rarely occurs in pre-puberty and infants. It is the fifth leading cause of cancer death in women. Due to its occult onset, lack of effective screening and early diagnosis, its 5-year survival rate still hovers at 20% -30%, and there is a worldwide statistics that 225,500 new cases of ovarian cancer occur each year, causing death 140 200 cases ~ ([1-2]). Therefore, the pathogenesis of ovarian cancer, chemotherapy resistance and prognosis of the study is essential.