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近几年来,药物控制释放领域的一个引人注目的进展是透皮给药体系的开发与商品化。自从第一只透皮给药体系东莨菪碱TTs历经六年的研究于1981年上市后,现在已有硝酸甘油、可乐定和硝酸异山梨醇等药物的透皮给药体系的商品出现在市场上,它们的销售量每年成倍的增长。近来各国都在竟相研制新的透皮给药体系,一些正在临床验证中,也有的正在等待药品管理机构的审批。
In recent years, one notable progress in the controlled release of drugs has been the development and commercialization of transdermal drug delivery systems. Since the first transdermal delivery system, scopolamine TTs, was launched in 1981 after six years of research, there are now commercially available transdermal delivery systems of drugs such as nitroglycerin, clonidine and isosorbide dinitrate, Their sales have doubled each year. Recently, all countries are actually developing new transdermal delivery system, some are in clinical validation, and some are waiting for the approval of drug regulatory agencies.