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目的探讨不同方式吸入布地奈德对咳嗽变异性哮喘(CVA)儿童的疗效、肺功能和血清炎性介质水平的影响。方法选取2012年1月—2015年1月诊断为CVA的儿童80名,其中将40名患儿在规范方式下持续吸入糖皮质激素划分为试验组,将另外40名患儿在间断方式吸入糖皮质激素为对照组,并在儿童治疗前、治疗3和6个月时比较两组儿童的咳嗽症状评分、肺功能和炎性介质指标比较。结果治疗前两组的咳嗽症状、肺功能和炎性介质主要指标比较差异无统计学意义(P>0.05);治疗3和6个月后,试验组和对照组CVA儿童的咳嗽症状评分、肺功能指标和血清炎性介质水平组内比较,差异有统计学意义(P<0.05);试验组的咳嗽症状评分、肺功能指标和血清炎性介质水平均显著优于对照组(P<0.05)。结论规范方式下长期持续吸入布地奈德比间断吸入布地奈德更能够有效地改善CVA儿童的咳嗽症状,降低气道阻塞情况,改善肺功能和血清炎性介质水平。
Objective To investigate the effects of inhalation of budesonide on efficacy, pulmonary function and serum inflammatory mediators in children with cough variant asthma (CVA). Methods Eighty children diagnosed with CVA between January 2012 and January 2015 were enrolled. Among them, 40 children were enrolled in the experimental group with continuous inhalation of glucocorticoid in a standardized manner and another 40 children were inhaled in intermittent mode Corticosteroids were used as control group. Cough symptom score, lung function and inflammatory mediators were compared between the two groups before 3 and 6 months of treatment. Results There was no significant difference in the main indexes of cough, lung function and inflammatory mediators between the two groups before treatment (P> 0.05). After 3 and 6 months of treatment, the cough symptom score, lung (P <0.05). The cough symptom scores, lung function indexes and serum inflammatory mediators in the experimental group were significantly better than those in the control group (P <0.05) . CONCLUSION: Long-term continuous inhalation of budesonide can significantly improve cough symptoms, reduce airway obstruction, and improve lung function and serum inflammatory mediators than intermittent inhalation of budesonide.