中国科学技术大学杜江峰研究组将量子技术应用于单个蛋白分子研究,在室温大气条件下获得了世界上首张单蛋白质分子的磁共振谱。研究人员利用钻石中的氮-空位点缺陷作为量子探针(以下简称“钻石探针”),选取了细胞分裂中的一种重要蛋白为探测对象。首先将蛋白从细胞中分离并将标记物(氮氧自由基)固定在蛋白的特定位置,然后将此蛋白分子放置到钻石表面,此时标记物距离“钻石探针”约10nm,会产生仅相当于地磁场十六分之一的极微弱的磁信号。“钻石探针”具有感知极弱磁信号的能力,在激光和微波操控下,它形成一个量子传感器,将单分子信号转化为光学信号而加以检测。经过两 Du Jiangfeng, University of Science and Technology of China, applied quantum technology to single protein molecules and obtained the first single-molecule magnetic resonance spectrum of the world in the atmosphere at room temperature. Researchers use nitrogen-vacancies in diamonds as quantum probes (hereinafter referred to as “diamond probes”) and select an important protein in cell division as the probe. First, the protein is separated from the cell and the label (nitroxide) is immobilized at a specific position in the protein, and then the protein is placed on the surface of the diamond. At this time, the label is about 10 nm from the “diamond probe” Produces a very weak magnetic signal equivalent to only one-sixth of the Earth’s magnetic field. “Diamond Probe ” has the ability to sense extremely weak magnetic signals, which under laser and microwave control form a quantum sensor that converts single-molecule signals into optical signals for detection. After two