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目的探讨彩色多普勒阴道超声及血清甲胎蛋白(AFP)测定对诊断恶性畸胎瘤的价值。方法对2000年~2005年我院收治畸胎瘤患者465例,其中未成熟畸胎瘤13例,成熟畸胎瘤恶变3例,进行回顾性分析,着重探讨彩色多普勒阴道超声下肿物声像图特征及血流情况。部分患者进行了血清AFP测定。结果彩色多普勒阴道超声术前诊断恶性畸胎瘤及恶性卵巢肿瘤10例(10/16),符合率62.5%。未成熟畸胎瘤组9例进行了AFP测定,阳性6/9例(66.7%);在成熟畸胎瘤恶变3例患者中,AFP均为阴性。结论彩色多普勒超声对恶性畸胎瘤诊断符合率较高,结合血清AFP含量测定,有助于对未成熟畸胎瘤,畸胎瘤恶变及卵黄囊瘤的鉴别。
Objective To investigate the value of color Doppler ultrasonography and serum alpha-fetoprotein (AFP) in the diagnosis of malignant teratoma. Methods From 2000 to 2005, 465 cases of teratoma were treated in our hospital, including 13 cases of immature teratoma and 3 cases of mature teratocarcinoma. Retrospective analysis was conducted to investigate the effect of color Doppler sonography Echographic features and blood flow. Some patients were serum AFP determination. Results 10 cases (10/16) were diagnosed malignant teratoma and malignant ovarian tumor by color Doppler before vaginal ultrasound, the coincidence rate was 62.5%. AFP was detected in 9 cases of immature teratoma group, 6/9 cases (66.7%) were positive, and AFP was negative in 3 cases of malignant teratoma. Conclusions The diagnostic accuracy of color Doppler ultrasound in diagnosis of malignant teratoma is high. Combined with the determination of serum AFP content, it is helpful for the identification of immature teratoma, malignant transformation of teratoma and yolk sac tumor.