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百草枯中毒引起急性肺损伤,据报道死亡率高。百草枯的毒性作用机制是氧化损伤和炎症。已知治疗性低温有抗氧化和抗炎症作用。设计这个研究是为了评估治疗性低温对百草枯中毒的效果。以50mg/kg给予雄性SD大鼠腹腔内注射百草枯,给予百草枯1小时后分成正常体温组(36~38℃)和低温组(30~32℃)。低温组进行2小时低温接着复温2小时。在生存研究中,给予百草枯后观察24小时死亡率。再次实验
Paraquat poisoning causes acute lung injury, with a high mortality rate reported. Paraquat’s toxic mechanism of action is oxidative damage and inflammation. Therapeutic hypothermia is known to have anti-oxidant and anti-inflammatory effects. This study was designed to assess the effect of therapeutic hypothermia on paraquat poisoning. Male SD rats were injected intraperitoneally with paraquat at 50 mg / kg. Paraquat was divided into normal body temperature group (36-38 ° C) and low temperature group (30-32 ° C) after being given paraquat for 1 hour. Low temperature group for 2 hours followed by rewarming for 2 hours. In the survival study, paraquat was administered to observe a 24-hour mortality rate. Experiment again