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肾上腺皮质激素治疗肾病综合征已有30余年的历史,最近又以极大量激素冲击疗法治疗难治性肾病。激素治疗肾病的原理可能是通过抑制淋巴系统,从而抑制免疫反应过程。此外,激素尚有减少炎症反应、降低肾小球基底膜的通透性,抑制醛固酮、抗利尿激素分泌,从而起到利尿、消肿、消除尿蛋白的作用。Schoenman等应用国际儿童肾脏病协会(ISKDC)的治疗方案,大剂量短程(8周)治疗309例微小病变型贤病病人,结果93%有效,但停药后
Corticosteroid treatment of nephrotic syndrome has been more than 30 years of history, most recently with a large amount of hormone therapy in the treatment of refractory kidney disease. Hormonal treatment of kidney disease may be through the inhibition of the lymphatic system, thereby inhibiting the immune response process. In addition, hormones still reduce inflammation, reduce glomerular basement membrane permeability, inhibition of aldosterone, anti-diuretic hormone secretion, which play diuretic, swelling, elimination of urinary protein. Schoenman and other applications of the International Society of Pediatric Nephrology (ISKDC) treatment, high-dose short-term (8 weeks) treatment of 309 patients with minimal changes in benign disease, the results were 93% effective, but after stopping