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目的研究PTEN蛋白表达在食管癌发生发展中的生物学意义。方法采用免疫组织化学S-P法,检测PTEN蛋白在87例食道癌组织中的表达水平。结果87例食管鳞癌中,PTEN阳性占48%。PTEN蛋白表达与TNM分期、肿瘤浸润深度有关。结论PTEN蛋白的表达缺失提示食管癌恶性程度较高,预后较差。PTEN蛋白的表达可作为判断食管癌预后的新指标。
Objective To study the biological significance of PTEN protein expression in the development of esophageal cancer. Methods Immunohistochemical S-P method was used to detect the expression of PTEN protein in 87 esophageal cancer tissues. Results In 87 cases of esophageal squamous cell carcinoma, PTEN positive accounted for 48%. PTEN protein expression is related to TNM stage and depth of tumor invasion. Conclusion The lack of PTEN protein expression indicates that the esophageal cancer has a high degree of malignancy and a poor prognosis. PTEN protein expression can be used as a new indicator to determine the prognosis of esophageal cancer.